ĭue to the debate surrounding the use of NSAIDs in sport and exercise applications, performance nutrition research has more recently shifted focus toward phytochemical-containing fruits and other functional foods that seem to provide a beneficial anti-inflammatory and antioxidant effect. However, NSAIDs remain controversial as some research has demonstrated that muscle protein synthesis and the function of satellite cells in skeletal muscle hypertrophy are compromised when COX enzymes are inhibited, while other studies have found no NSAID effect on post-exercise anabolic processes within muscle. NSAID use mitigates the inflammatory response via non-specific inhibition of the cyclooxygenase (COX-1 and COX-2) enzymes that regulate production of inflammatory-stimulating prostaglandins. Millions of people, including athletes, use non-steroidal anti-inflammatory drugs (NSAIDs) to help reduce pain and inflammation. Muscle soreness following exercise is not the direct result of inflammation, but rather a product of high nociceptor and mechanoreceptor sensitivity to the potent chemicals and by-products released during muscular degeneration. The repetitive nature of muscle contractions during bouts of high intensity exercise will induce muscular injury as a result of ultrastructural disruptions that ultimately lead to a muscular repair sequence of events: degeneration, inflammation, regeneration, and fibrosis. Short-term supplementation of Montmorency powdered tart cherries surrounding a single bout of resistance exercise, appears to be an effective dietary supplement to attenuate muscle soreness, strength decrement during recovery, and markers of muscle catabolism in resistance trained individuals.Ī large volume, high intensity strength training workout activates a load-induced stress response characterized by structural muscle damage, oxidative stress, and inflammation that facilitates the release of intramuscular proteins into systemic circulation that are usually associated with cardiovascular dysfunction, invasive surgery, and disease. Changes in TC whole blood lymphocyte counts ( p = 0.013) from pre-lift were greater compared to P, but TC lymphocyte counts returned to pre-lift values quicker than P. None of the free radical production, lipid peroxidation, or antioxidant capacity markers (NT, TBARS, TAS, SOD) demonstrated significant changes with supplementation. No significant supplementation effects were observed for serum inflammatory or anti-inflammatory markers. TC changes in serum creatinine ( p = 0.03, delta p = 0.024) and total protein ( p = 0.018, delta p = 0.006) were lower over time and smaller from pre-lift levels over time compared to P Significant TC group reductions from pre-lift levels were found for AST and creatinine 48-h post-lift, bilirubin and ALT 60-min and 48-h post-lift. Compared to pre-lift, TC vastus medialis (¼) soreness was significantly attenuated up to 48-h post-lift with vastus lateralis (¼) soreness significantly lower at 24-h post-lift compared to P. Muscle soreness perception in the vastus medialis (¼) ( p = 0.10) and the vastus lateralis (¼) ( p = 0.024) was lower in TC over time compared to P. Fasting blood samples, isokinetic MVCs, and quadriceps muscle soreness ratings were taken pre-lift, 60-min, 24-h, and 48-h post-lift and analyzed by MANOVA with repeated measures. Subjects performed ten sets of ten repetitions at 70 % of a 1-RM back squat exercise. Participants supplemented one time daily (480 mg/d) for 10-d including day of exercise up to 48-h post-exercise. Subjects were randomly assigned to ingest, in a double blind manner, capsules containing a placebo (P, n = 12) or powdered tart cherries (TC, n = 11). Twenty-three healthy, resistance-trained men (20.9 ± 2.6 yr, 14.2 ± 5.4 % body fat, 63.9 ± 8.6 kg FFM) were matched based on relative maximal back squat strength, age, body weight, and fat free mass. The purpose of this study was to examine whether short-term ingestion of a powdered tart cherry supplement prior to and following intense resistance-exercise attenuates muscle soreness and recovery strength loss, while reducing markers of muscle damage, inflammation, and oxidative stress.
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